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Molecular Aggregation of L-isoleucine in Aqueous Solution and its Impact on the Determination of Solubility and Nucleation Kinetics

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Fig. 1. (a) Heating rates applied shows almost no effect to the dissolving L-isoleucine in water, (b) Crystallization, gravimetric solubility and dissolution curves of L-isoleucine, showing that the solubility derived from dissolution measurements is lower
Fig. 2. Visual images of L-isoleucine solution at different temperatures and times, (a) 25 °C after 1 h, (b) 51 °C after 1 h, (c) 51 °C after 144 h highlighting that thecrystals did not fully dissolve at solution saturation temperature, Tsol 51 °C as determined using gravimetric data; (d) at the measured dissolution temperature, Tdiss64 °C.
Fig. 3. (a) Conductivity of L-isoleucine solutions at different solute concentrations and temperatures revealing evidence for the molecular aggregation in the solution.(b) Solubility data of L-isoleucine as determined using the gravimetric and dissolution
Fig. 3(b). Overall, the data suggests that the aggregates formed at highconcentrations could be easily dissolved into the free molecule forms,which could indicate the aggregates are formed based on the weak
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