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Sostdc1: A soluble BMP and Wnt antagonist that is induced by the interaction between myeloma cells and osteoblast lineage cells

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Figure

Fig. 1. Sostdc1 protein levels are increased by myeloma cells-OB progenitor interaction and blocking Sostdc1 reverses myeloma-induced suppression of OB dif-ferentiation: (A) Flow cytometry analysis of 5TGM1-GFP cells and OB progenitors (alone or in co-cult
Fig. 2. Sostdc1 was upregulated in 5TGM1 tibiae sections and 5TGM1-OB progenitor co-cultures: Immunoassays and end-point PCR were performed to detectsections
Fig. 3. Sostdc1 reduces OB progenitor dientiating OB progenitors treated with Wnt3a (A), BMP2 (B) and BMP7 (C) alone or in the absence or presence of Sostdc1, Dkk1 or noggin
Fig. 5. Sostdc1 inhibits BMP-inducedblot analysis of cell lysates from OB progenitors stimulated by Wnt3a (i), BMP2 (ii) or BMP7 (iii) in the absence or presence of Sostdc1, Dkk1 or noggin illustrating thelevel of Phospho-Smads 1, 5 & 8 (i) or β-catenin (C

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