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Human Cytomegalovirus Protein pUL38 Induces ATF4 Expression, Inhibits Persistent JNK Phosphorylation, and Suppresses Endoplasmic Reticulum Stress-Induced Cell Death

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Figure

FIG. 1. Diagram of signaling pathways activated in the UPR. ThreeER lumen-located sensor molecules, PERK, ATF6, and IRE-1, are acti-
FIG. 2. Construction and analysis of the BAC-HCMV clone pADpmregion encoding UL36-UL38 and the sequence of the UL38 coding sequence where the mutations were introduced
FIG. 3. The UL38 mutant HCMV virus ADpmC) HFs were infected with indicated recombinant HCMV viruses at an MOI of 3; at the indicated times postinfection the cell morphology wasexamined under a phase-contrast microscope (B), and cell survival was quantified
FIG. 4. pUL38 expression alone blocked cell death induced by thestress on the endoplasmic reticulum
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