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TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1

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Figure

Figure 1. Murine Tdp2 repairs Top1-mediated DNA damage in the absence of Tdp1. (Tdp1products resolved and detected by denaturing PAGE and phosphorimaging
Figure 2. Avian Tdp2 repairs Top1-mediated DNA damage in absence of Tdp1. (3digested with NcoI and Southern blotting was conducted using the probe depicted in (a) (for Tdp1, top) or as described in ref 13 (for Tdp2, bottom).(harbouring a 3detected by phosp
Figure 3. Over-expression of hTDP2 protects avian DT40 cells lacking Tdp1 from Top1-mediated DNA damage
Figure 4. Tdp2 preferentially repairs transcription-associated Top1-DNA breaks. MEFs (followed by an additional incubation with 20Tdp1cells/sample/experiment and data are the average ofweight for a period of 10 days, followed by weekly monitoring of surviv

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