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Regulation of Norovirus Virulence by the VP1 Protruding Domain Correlates with B Cell Infection Efficiency

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Figure

FIG 1 VP1 mutations arising during persistent MNV-1 infection. (A) Loca-tions of mutations along the linear VP1 protein
TABLE 1 Mutagenesis primers for generating recombinant MuNoV strains
FIG 2 VP1 P2 domain residue 296 does not affect viral replication in culturedThe entire experiment was repeated three times, and data from all experimentswere averaged
FIG 3 VP1 P2 domain residue 296 is necessary and sufficient for MuNoVvirulence. (A) Groups of IFNAR�/� mice (n � 2 or 3) were inoculated with5 � 105 TCID50 units of MNV-1 (black), MNV-1.K296E (blue), MNV-3 (red),or MNV-3.E296K (green) p.o
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