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DNA Damage Signaling Is Required for Replication of Human Bocavirus 1 DNA in Dividing HEK293 Cells

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Figure

FIG 1 HBoV1 does not infect HEK293 cells. HEK293 cells were mock infected (A) or infected with HBoV1 atan MOI of �400 vgc/cell (B)
FIG 2 Transfection of pIHBoV1 induces a DDR in HEK293 cells. HEK293 cells were transfected with the HBoV1 infectious clone pIHBoV1�anti-NS1C and anti-p-RPA32 antibodies (B)
FIG 3 HEK293 cells transfected with pIHBoV1 undergo activation of ATM, ATR, and DNA-PKcs
FIG 4 IF analyses of HBoV1 NS1-induced DDR in HEK293 cells. HEK293 cells were transduced with lentiviruses encoding viral NS1, NS1-70,NS2, NS3, NS4, NP1, and VP or GFP (control)
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