Human cytomegalovirus immediate-early 2 (IE2) protein can transactivate the human hsp70 promoter by alleviation of Dr1-mediated repression.

Considering that chromosomal replication origins are generally located in a nontranscribed region (4, 10, 51), the HVS oriP may represent a unique replication origin, although

Of the 55 point mutations which distinguish the type 1 poliovirus vaccine strain (Sabin 1) from its neurovirulent progenitor (P1/Mahoney), two have been strongly implicated by

To determine directly and exactly how far into the tRNA molecule plus-strand synthesis proceeds, we developed a new type of primer extension analysis performed inside VLPs by using

These findings demonstrate (i) the value of SCID mice for genetic analysis of viral virulence, (ii) that virulence and organ tropism in SCID mice are controlled by gene segments

In these cultures, which were washed stringently each day to remove free virus and degenerating virus-infected cells, ap- proximately 1 in 100 cells inoculated with SIVmac239/17E-Br

the cell surface but was present in virions purified from extracellular fluid and from the cytoplasm; and (iv) UL20 protein was found to be present in the nuclear membranes, in

Neither El nor E2 was detected when MAbs A4, All, and 119 were used for cell surface immunostaining of HepG2 or BHK-21 cells infected with vHCV1-1488 (Fig. llB, lower right)

Therefore, although T lymphocytes appear to be an important early target in tissues, the high viral load that accompanies either primary or terminal clinical illness is