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Drug screening of biopsy-derived spheroids using a self-generated microfluidic concentration gradient

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Academic year: 2019

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Figure

Figure 1. Microfluidic device layout and functions. (A) Schematic representation of the device structure, comprising a microchannel network and an array of square micro-wells, with a width of 150 µm and a depth of 180 µm
Figure 2. Overflow ports enabled the formation of long-lasting chemical concentration gradients without following a cisplatin concentration gradient for 12 hours
Figure 3. Screening readouts. (mean. (LNCaP-docetaxel experiments in gradient devices (day 3 and 8), confirming successful gradient formation and concentration response curves obtained by exposing UVW spheroids to cisplatin and LNCaP spheroids to docetaxel
Figure 4. Primary prostate biopsy experiment results. (A) Shape factor temporal evolution obtained averaging all the spheroid responses in the highest (Row1), middle (Row4&6) and lowest (Row8) concentration of docetaxel in the case of repeated drug applica

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