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Rapid high-throughput characterisation, classification and selection of recombinant mammalian cell line phenotypes using intact cell MALDI-ToF mass spectrometry fingerprinting and PLS-DA modelling

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Academic year: 2019

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Figure

Table 1. PLS-DA predicted classification for samples as ‘high’ class (> 4000 mg/L) for cell line
Figure 1. The classical cell line construction workflow utilzed for the construction of naïve
Figure 3. Representaive MALDI-ToF mass spectrometry data before and after pre-processing before
Figure 4. (A) The distribution of monoclonal antibody (mAb) productivity in 10 L fed-batch
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