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Identification of CXCR4 Domains That Support Coreceptor and Chemokine Receptor Functions

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FIG. 2. SDF-1 activation requires residues in the second extracellular and second intracellular loops of CXCR4, is pertussis toxin sensitive, and does not requirethe distal C terminus of CXCR4
FIG. 3. (A) SDF-1 binding requires the proximal amino terminus of CXCR4.293T cells transiently transfected with the indicated constructs were tested for
FIG. 4. HIV-1 Env utilizes multiple regions of the coreceptor CXCR4 for viral fusion. HIV-luciferase reporter viruses pseudotyped with the X4 Envs of HXB2 andNL4-3 were used to infect U87-MG cells transiently transfected with the constructs indicated
FIG. 5. Binding of X4 gp120s directly to CXCR4. The X4 gp120s from BH8 and MN were iodinated and used for binding to 4 �(5 to 10expressing CXCR4
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