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Recent advances in ω-transaminase-mediated biocatalysis for the enantioselective synthesis of chiral amines

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Figure

Figure 1. Schematic of transamination catalyzed by transaminases.
Figure 2.�(( Synthetic approaches for��� ω-TA-mediated amine synthesis: (A) Kinetic resolution withS)-ω-TA; (B) Asymmetric synthesis and (C) Deracemization of racemic amine using (R)-ω-TA andS)-ω-TA
Figure 3. Various strategies used to shift the equilibrium ofpressure; ( ω-TA mediated transamination: (AI)Removal of ketone byproduct by evaporation; (AII) Removal of ketone byproduct under reducedAIII) Removal of ketone byproduct using biphasic reaction system; (B) Recycling of pyruvatesubstrate; and (C) Use of ‘smart’ amine donors (BCTA- Branched-chain amino acid transaminases;LDH-Lactate dehydrogenase; GDH-Glucose dehydrogenase).
Figure 4.permission from [ Use of a deracemization strategy for the synthesis of enantiopure Mexiletine (reprinted with61], Copyright (2009) American Chemical Society)
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