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Sequences within the gag Gene of Mouse Mammary Tumor Virus Needed for Mammary Gland Cell Transformation

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FIG. 1. Strategy for making chimeric viruses. (A) The 5�ER, NcoIF, and NcoIR were used for PCR-directed mutagenesis, as described in Materials and Methods, to replacetheMA, CA, and NC domains and amino acid differences between MMTV(C3H) andXbaI site
FIG. 5. Mammary gland tumor incidence in BALB/cJ, C3H/HeN, and (B � C)F1 females infected with MMTV(C3H), MMTV(HeJ), or HP.The mice were fostered on the milk of viremic mothers and monitored for mammary gland tumors by weekly palpation.
FIG. 6. Haplotype map of (B �genomewide scan with MIT markers spaced at 15- to 35-Mb intervals throughout the genome
FIG. 7. Model of how MTS may contribute to the induction ofmammary tumors. MTS may contribute directly (A) or indirectly

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