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On the phase space structure of IP3 induced Ca2+ signalling and concepts for predictive modeling

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Figure

FIG. 1. Hierarchical organization of IP3number of open channels. The stochastic local events are or-chestrated by diffusion and CICR into cell wide Ca(bottom)
FIG. 2.Variability in Catrocytes stimulated with 10dependence with a different slope than HeLa cells
FIG. 3. ISI distributions P(ISI) for two spike trains measuredwith HEK cells stimulated with 100the fitting method is explained in ref
FIG. 4. This state scheme of the IP3open state Oone closed state Cstate-transitions within each mode are constants.are the rates connecting the two modes and depend on CaR originally publishedby Siekmann et al.68 is comprised of two modes
+2

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