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Hepatitis C Virus Causes Uncoupling of Mitotic Checkpoint and Chromosomal Polyploidy through the Rb Pathway

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Figure

FIG. 1. Representative polyploidy in PBMCs of hepatitis C patients and HCV-infected culture cell lines
FIG. 3. Polyploidy induced by the expression of HCV core protein in mouse primary cells
FIG. 5. Mitotic spindle checkpoint defects in HCV-infected Huh7.5.1 cells or HCV core protein-expressing HEK293 cells
FIG. 7. Postulated mechanism of core-induced mitotic defects.

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