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Dual Stem Loops within the Poliovirus Internal Ribosomal Entry Site Control Neurovirulence

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Figure

FIG. 1. PV1/HRV2 chimeras featuring heterologous or synthetic IRESes ofvarious composition
TABLE 1. Neurovirulence testing in Cynomolgus monkeys
FIG. 3. Sequence alignment of IRES domains V and VI of PV1(M) (17) and HRV2 (33). GenBank accession numbers for the sequences used are J02281 forPV1(M) and X02316 for HRV2
FIG. 4. Construction of PV1(M)/HRV2 intradomain chimeras featuring heterologous uppermost regions of domains V and VI linked to the stem structuresoriginating from HRV2 and PV1(M), respectively
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