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The CC-Chemokine RANTES Increases the Attachment of Human Immunodeficiency Virus Type 1 to Target Cells via Glycosaminoglycans and Also Activates a Signal Transduction Pathway That Enhances Viral Infectivity

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Academic year: 2019

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Figure

FIG. 3. RANTES binds to virions. (a) RANTES was captured on magneticbeads via an anti-murine immunoglobulin G antibody and a murine anti-RAN-
FIG. 5. RANTES-mediated infectivity enhancement is dependent upon GAG expression on target cells
FIG. 6. RANTES-mediated infectivity enhancement is inhibited by soluble GAGs. HeLa-CD4 cells were infected with HIV-1MuLV100%)
FIG. 8. Effect of RANTES on HIV-1 Env-mediated cell-cell fusion. HeLa target cells expressing the HIV-1IIIB0 h means that the chemokine was only added to the mixed effector-target cell population during the fusion process; the designation 24 h indicates th

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