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GPER mediates the angiocrine actions induced by IGF1 through the HIF 1α/VEGF pathway in the breast tumor microenvironment

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Figure

Fig. 1 GPER correlates with IGF1R and CD34 expression in breast tumor samples. Data showing angiocrine-related genes across the 17 studyceptor,indicates low
Fig. 2 IGF1 induces the expression of HIF-1performed in triplicate. Representative immunoblots showing the increase of HIF-1with 100 ng/mL IGF1 for 8 hours
Fig. 3 ERK1/2 and AKT signaling pathways are involved in the upregulation of VEGF expression induced by IGF1
Fig. 4 < 0.05, p < 0.01 (**).G-protein estrogen receptor,with 100 ng/mL IGF1 for 8 hours, as indicated.treated with 100 ng/mL IGF1 for 18 hours is abrogated silencing the expression of HIF-1 HIF-1 hypoxia inducible factor-1, IGF1 insulin-like growth factor
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