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Akt inhibitors as an HIV 1 infected macrophage specific anti viral therapy

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Figure 1Treatment of HIV-infected macrophages with PI3K/Akt inhibitors reduces HIV-1 production and induces cell deathwith one of four different PI3K/Akt kinase inhibitors in the presence or absence of stress (SNP, 1 mM): wortmannin (100 nM), tants were co
Figure 3PH domain, resulting in increased Akt activityHIV-1 infection promotes membrane recruitment of Akt's HIV-1 infection promotes membrane recruitment of Akt's PH domain, resulting in increased Akt activity
Figure 5bility using the trypan blue assay. Results are shown as per-cent cell death. (C) CHME5 sublines expressing wildtype or αmutant Tat CHME5 sublines were lysed and analyzed for PTEN protein levels by Western blot
Figure 6SIV Tat also exerts a cytoprotective effectSIV Tat also exerts a cytoprotective effect
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