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Potential therapeutic targets for hypoxia induced pulmonary artery hypertension

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Academic year: 2020

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Figure

Figure 1 Effects of mitochondrial ATP-sensitive potassium channel inhibitor (5-HD) on the development of pulmonary hypertension.density (OD) of a-actin;tissues (×6000)
Figure 2 Effect of 5-HD on mRNA (A) and protein expression (B) of Kv1.5 in pulmonary arteries
Figure 4 Effect of 5-HD on Δ ψ m and proliferation in PASMCs. (A) Morphology of isolated PASMCs
Figure 5 5-HD down-regulates hypoxic-induced pulmonary artery hypertension. 5-HD could inhibit mitoKATP channels and block thehypoxic depolarization of mitochondrial membrane potential of PASMCs via Kv1.5 channels, inhibiting the circulating inflammatory cytokinesMCP-1 and down-regulating TGF-β1 signaling way, or inhibiting PAH by oxygen free radicals (ROS)-related signal pathways.

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