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Should we treat pyrexia? And how do we do it?

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Figure

Fig. 1 The main stages of the molecular basis of pyrexia. IL interleukin, PGE2 prostaglandin E2, TNF tumour necrosis factor
Fig. 2 Suggested impact of pyrexia treatment on outcome according to clinical context.nervous system, ARDS acute respiratory distress syndrome, CNS central OHCA Out-of-hospital cardiac arrest
Table 1 Main RCTs comparing antipyretics with no treatment in adult critically ill patients
Table 2 Proposed criteria for choosing betweenpharmacological and non-pharmacological antipyretic methods

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