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Generation of an Adenovirus-Parvovirus Chimera with Enhanced Oncolytic Potential

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Figure

FIG 1 Construction of an inducible parvovirus P4 promoter (P4-TO). (A) Schematic view of the P4-TO promoter generated by inserting two tetracyclineoperator 2 (TetO2) elements into the P4 promoter of the hH-1 genome
FIG 2 Characterization of the hH-1-TO virus. (A) Inducible expression of the phH-1-TO plasmid containing the P4-TO promoter
FIG 3 Generation of Ad-PV chimeras. (A) Inducible gene expression from the chimeric pAd-hH-1-TO plasmid
FIG 4 Production, spreading, and cytotoxicity of progeny parvoviruses in cells infected with the Ad-PV chimera
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