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Small cell lung cancer growth is inhibited by miR 342 through its effect of the target gene IA 2

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Figure

Fig. 1 IA-2 expression is decreased by siRNA. a The knockdown of endogenous IA-2 mRNA by siRNA (determined by quantitative RT-PCR analysis), was reduced ~80 % in NCI-H82
Fig. 2 IA-2 silencing by RNAi leads to reduced SCLC cell proliferation and ACh secretion
Fig. 3 miR-342 regulates IA-2 expression level in SCLC cells. a, b Effects of miR-342 mimic and miR-342 inhibitor on IA-2 expression in NCI-H82 and NCI-H345 cells (n = 4), as quantitated by Real-Time PCR
Fig. 4 Inhibitory effect of miR-342 mimic on SCLC growth and ACh secretion. a, b Cell growth rates (based on cell count), were significantly reduced in both NCI-H82 and NCI-H345 cell lines transfected with the miR-342 mimic
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