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Study of the V3 Loop as a Target Epitope for Antibodies Involved in the Neutralization of Primary Isolates versus T-Cell-Line-Adapted Strains of Human Immunodeficiency Virus Type 1

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Academic year: 2019

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Figure

FIG. 1. V3 loop amino acid sequences of peptides and viruses used in the study, aligned with the subtype B (United States/European) consensus sequence.
TABLE 1. Neutralizing activities detected in serafrom HIV-positive patients
FIG. 4. Competition experiments with the TCLA strain HIVHIVbefore neutralization and competition experiments with exactly the same exper-imental conditions as for primary isolates
FIG. 5. Consequences of the removal of V3-specific antibodies from immune sera. Neutralization was measured in sera not depleted, mock depleted, and depletedwith the autologous and heterologous V3 peptides (peptide Bx08-1 and peptide R21)

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