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Conformational Epitope-Specific Broadly Neutralizing Plasma Antibodies Obtained from an HIV-1 Clade C-Infected Elite Neutralizer Mediate Autologous Virus Escape through Mutations in the V1 Loop

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Figure

TABLE 1 Neutralization breadth of Protocol G G37080 plasma samplescollected at two different time points tested against panel of 57 Env-pseudotyped viruses
FIG 2 Assessing dependence of G37080 BCN antibodies to CD4 binding site (CD4bs) region of HIV-1 Env
TABLE 3 Degree of shift in sensitivity of Env-pseudotyped viruses toG37080 BCN plasma depleted with monomeric and trimeric Envs andC1C peptide
FIG 3 Binding of G37080 BCN plasma IgG to 4-2.J41 monomeric gp120 (A) and BG505-SOSIP.664-D7324 cleaved trimeric gp140 (B) soluble proteins wasassessed by ELISA
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