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High Fidelity of Yellow Fever Virus RNA Polymerase

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Figure

FIG. 1. Passagesofsaged similarly, except that plaque purification passages (P3 to P5)DEN2cells with in vitro RNA transcripts synthesized using SP6 RNA poly-merase
TABLE 1. Nucleotide and amino acid changes in uncloned and cloned ChimeriVax-DEN viruses
TABLE 2. Assigned classification of mutations detected duringpreparation of ChimeriVax-DEN viruses and the genetic stability
FIG. 2. Clustering of beneficial amino acid changes in the four ChimeriVax-DEN chimeras that accumulated in all cloned and uncloned virusesduring genetic stability passages

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