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Increased non-homologous end joining makes DNA-PK a promising target for therapeutic intervention in uveal melanoma

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Academic year: 2019

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Figure

Figure 1. Non-homologous end joining (NHEJ) is elevated in uveal melanoma (UM) cell lines and short-term cultures (STCs)
Figure 2. Confirmatory expression of NHEJ pathway genes in the Cancer Genome Atlas (TCGA)
Figure 3. The sensitivity of UM cells to inhibition of DNA-PK. (were sensitive to DNA-PK inhibitor NU7026 when compared to the cutaneous melanoma (CM) cell line WM793, LA1-5s and an array of sarcoma cell lines (**A) UM cell lines SOM 157D and 196B P = <0.0
Figure 4. The sensitivity of the UM cell lines to DNA-PK inhibitor NU7441. (percentage of apoptotic cells as suggested by Annexin V positivity was significantly increased in the UM cell lines SOM 157D and 196B in response to treatment with 2.5 µM NU7441 fo

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