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Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies

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Figure

Table 1. Illustration of liability threshold model: simulatedT2D example.
Table 2. Average x2 statistics for LT versus other approaches in simulated data.
Figure 2. Power calculations for LogR, G+PGxE, and LT approaches in simulated data. For each statistic we display power to attain,561028 based on 1,000,000 simulations of 3000 cases and 3000 controls, for various effect sizes c
Table 3. Inferred covariates and effect sizes on the liability scale.
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