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The Secreted Form of Dengue Virus Nonstructural Protein NS1 Is Endocytosed by Hepatocytes and Accumulates in Late Endosomes: Implications for Viral Infectivity

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FIG. 1. Detection of the DEN sNS1 protein in mouse liver. Mice were injected intravenously with purified DEN-1 sNS1 (25 �sacrificed at 1, 3, 6, or 24 h postinjection
FIG. 3. Stability of the internalized sNS1 protein in human hepa-tocytes. Huh7 cells were incubated for 6 h with DEN-1 sNS1 (10
FIG. 4. sNS1 protein accumulates in LBPA-rich structures. Huh7 cells were incubated for 6 h with DEN-1 sNS1 (10 �by 24 h or 48 h of chase (6 h/24 h and 6 h/48 h, respectively)
FIG. 7. sNS1 protein enhances dengue virus production by humanhepatocytes. Huh7 cells were incubated for 24 h with DEN-1 sNS1 (10

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