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The EBNA1 Protein of Epstein-Barr Virus Functionally Interacts with Brd4

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Figure

FIG. 1. EBNA1 domains and mutants. Schematic representation ofthe wild-type EBNA1 protein is shown on top along with some of the
FIG. 3. Brd4 enables EBNA1-mediated plasmid maintenance in yeast. Plasmid loss assays in yeast were conducted as described for Fig
FIG. 4. Coimmunoprecipitation of EBNA1 and EBNA1 mutantswith Brd4 in human cells. 293T cells were cotransfected with a plasmid
FIG. 5. Effect of Brd4 silencing on transcriptional activation by EBNA1. (A) CNE2Z cells were treated with esiRNA against Brd4 or siRNAagainst GFP, and downregulation of Brd4 was confirmed by Western blotting equal amounts of cell lysates
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