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An intrinsic timer specifies distal structures of the vertebrate limb

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Figure

Figure 1 | The environment appears to determine distal graft fate. Blocks (150of wild-type HH24 buds ((representations) HH20 chick wing distal mesenchyme denuded of ectoderm and grafted under the AER of wild-type HH20 buds (distal to the stylopod ( mm) of
Figure 2 | Hoxa13absence in proximal part of the graft. Scale bars: 100shown 24 h (expression at 24 h
Figure 3 | AER duration is locally controlled by the distal mesenchyme. In grafts of HH24 distal mesenchyme cells made to the same stage wing budsHH20 distal mesenchyme tissue grafted beneath the AER of wild-type HH24 buds (grafted tissue is shown by GFP e
Figure 4 | Cell cycle parameters are intrinsically timed. Cell cycle
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