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Tools for translational epigenetic studies involving formalin fixed paraffin embedded human tissue: applying the Infinium HumanMethyation450 Beadchip assay to large population based studies

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Academic year: 2020

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Figure

Fig. 1 Workflow diagram for assessing the suitability of FFPE tumour-enriched DNA on the HM450K platform
Fig. 2 Post HM450K assay data quality checks of FFPE tumour-enriched DNA. Scatterplots of replicates assayed on different beadchips (n a Average probe detection p-values across all probes for each sample
Table 1 Age of tumour material, performance at QC checkpoints and number of failed HM450K probes in failed and a subset of successful samples on HM450K platform
Fig. 3 Probe mean beta values at the BRCA1 gene. a Mean beta values measured from 419 tumour-enriched DNA in our dataset

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