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Minor groove binders: some recent research in drug development

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Figure

Table 2. Results obtained from the thermal melting experiments showing the change in melting temperature in the presence of the monoamidine-like cations [14-21] to Salmon Sperm DNA (∆Tm(SS), oC); melting temperature in phosphate buffer (10 mM) is 69oC
Figure 1. Structure of furamidine (left) and general structure of the related compounds previously reported by Rozas’ group [27] that have shown good affinity toward DNA
Figure 3. Conceptual breakdown of potent compound 22. The arrow indicates the axis of symmetry for the molecule
Table 3. DNA binding affinity and in vitro  antimicrobial activity of 23-32.
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