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A Tyrosine-to-Histidine Switch at Position 18 of the Ross River Virus E2 Glycoprotein Is a Determinant of Virus Fitness in Disparate Hosts

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Figure

FIG 1 RRV E2 Y18H is an attenuating mutation in a mouse model. Three- to four-week old C57BL/6J mice were inoculated with PBS or 10Y18H (evaluated for statistically significant differences by two-way ANOVA followed by Bonferroni’s test.3 PFU of RRV-T48,E3 R
TABLE 1 Amino acid residue at position 18 (or equivalent) of the alphavirus E2 glycoprotein
TABLE 1 (Continued)
FIG 2 The E2 Y18H mutation reduces RRV tissue titers and spread. Three- to four-week old C57BL/6J mice were inoculated with 103 PFU of RRV-T48 or E2Y18H mutant virus by injection in the left rear footpad
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