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Mutation of lysine residues in the nucleotide binding segments of the poliovirus RNA-dependent RNA polymerase.

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Figure

FIG. 1. Lysine-to-leucine mutations in poliovirus 3Dpolan open bar (1 to 461); expanded regions illustrate peptides containing cross-linked NTP
FIG. 4. Elongation activities of wild-type 3D and mutant 3D proteins.Poly(U) polymerase activities in ammonium sulfate-fractionated extracts con-
TABLE 1. Sequences recovered in large-plaque revertantsof virus containing 3D�276
FIG. 6. Translation of wild-type (w.t.) and 3D�obtained after translation of transcripts from wild-type, 3D3Dextracts
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