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Unraveling Viral Interleukin-6 Binding to gp130 and Activation of STAT-Signaling Pathways Independently of the Interleukin-6 Receptor

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Academic year: 2019

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Figure

FIG. 1. Binding of vIL-6 to gp130. (A) Ribbon model of the recently solved vIL-6/gp130 X-ray structure
FIG. 2. Characterization of the vIL-6/hIL-6 chimeras IV1-4. (A) Schematic representation of vIL-6, hIL-6, and chimeras IV1 to IV4
FIG. 3. Characterization of the vIL-6/hIL-6 chimeras IV5 to IV9. (A) Schematic representation of vIL-6, hIL-6, and chimeras IV5 to IV9.Sequence stretches that are part of the exchanged areas of vIL-6 and hIL-6 are indicated in black

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