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The relevance of microRNAs and circadian rhythms in drug safety

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Figure

Figure 1: Metabolism and bioactivation of APAP.  The major pathways of activation include glucuronidation (~50%) and sulphation (~30%) pathways
Figure 2: The Rumack-Matthew nomogram (reconstructed) used to determine risk in APAP poisoned patients from a single drug ingestion
Table 7: Ideal characteristics of novel clinical biomarkers for APAP-induced ALI. Adapted
Figure 3: Examples of miRNA annotation
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