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Activation of CD8+ T-Cell with abacavir and HLA-B*57:01 binding peptides and elimination of T-Cell responses through chemical modification

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Figure

Figure 1.1 Crystal structure of abacavir (orange spheres) bound to HLA-B*57:01 molecule
Figure 1.8 Maculopapular rash from exposure to Ampicillin (Fellner, 1986).
Table 1.7 Biological drugs
Figure 1.10 Mechanism of action of an IgG antibody (Hansel et al, 2010).
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Outline

Drugs associated with hypersensitivity reactions Methodology Discussion and abacavir are shown from a single experiment Abacavir was used as a positive control in each experiment Chemical structures of the compounds are drawn beside Activation of Abacavir-Specific CD8 + T-Cell by A Unique HLA-B*57:01 Binding Peptides mM Amoxicillin 20 μM peptide15 (amidated) Final Discussion

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