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Overlapping Local and Long-Range RNA-RNA Interactions Modulate Dengue Virus Genome Cyclization and Replication

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FIG 1 Conserved RNA structures in the DENV capsid coding sequence. (A) Nucleotide conservation of the first 450 nucleotides of the viral genome usingrepresentative sequences of the six different DENV2 genotypes
FIG 2 Functional significance of RNA structures in the capsid coding sequence. (A) Schematic representation of the DENV reporter FullCapDVLuc
FIG 3 Sequence in the capsid protein coding region facilitates long-range RNA-RNA interactions between the ends of the viral genome
FIG 4 Relevance of C1-DB1 interaction in DENV RNA replication. (A) Design of mutation disrupting and reconstituting long-range C1-DB1 RNA-RNAand the substitutions incorporated are shown in the two alternative conformations, linear and circular

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