ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures.

Herein, we report that the live- attenuated herpes simplex virus 1 (HSV-1) VC2 vaccine strain, which has been shown to be unable to enter into neurons and establish latency in mice,

During lytic infection in epithelial cells the expression of herpes simplex virus type 1 (HSV-1) immediate- early (IE) genes is initiated by a multiprotein complex comprising

Acti- vation of the cellular transcription factor AP-1 in herpes simplex virus infected cells is dependent on the viral immediate-early protein ICP0.. Nucleic

This study examined the safety of intracerebral inoculation of G207, an attenuated, replication-competent herpes simplex virus type 1 (HSV-1) recombinant, in nonhuman primates..

BioMed CentralVirology Journal ss Open AcceResearch Herpes simplex virus type 1(HSV 1) oncolytic and highly fusogenic mutants carrying the NV1020 genomic deletion effectively

Isolation and characterization of a herpes simplex virus type 1 mutant containing a deletion within the gene encoding the immediate early polypeptide VmwllO. Evidence of

Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4. Activation of imme- diate-early,

Regulation of the herpes simplex virus type 1 late (gamma2) glycoprotein C gene: sequences between base pairs -34 to +29 control transient expression and responsiveness to