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Functional Comparison of HBZ and the Related APH-2 Protein Provides Insight into Human T-Cell Leukemia Virus Type 1 Pathogenesis

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Figure

TABLE 1 Overview of HBZ and APH-2 regulatory functions
FIG 2 APH-2, unlike HBZ, did not enhance TGF-� signaling. (A to C) HepG2 cells were transfected with 200 ng TK-renilla control, 500 ng 9�CAGA-lucreporter (a TGF-�-responsive reporter), and titrating amounts of FLAG-HBZ, FLAG–APH-2, HBZ, APH-2, or the contr
FIG 3 HBZ and APH-2 repressed p65 transactivation. (A) HEK293T cells were transfected with 20 ng TK-renilla control, 200 ngwas performed to detect the expression levels (FLAG) of HBZ and APH-2 under each condition relative to that obtained with the loading
FIG 4 HBZ, but not APH-2, repressed IRF-1 transactivation. (A) HEK293T cells were transfected with 20 ng TK-renilla control, 200 ng IRF-1 luciferase reporter, 25 ngIRF-1expressionplasmid,andtitratingamountsofFLAG-HBZ,FLAG–APH-2,orthecontrolexpressionvector
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