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Shikonin induced necroptosis is enhanced by the inhibition of autophagy in non small cell lung cancer cells

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Figure

Fig. 1 Effect of shikonin on the viability, cytotoxicity, and caspase 8 activity of A549 cells
Fig. 2 Cell death induced by shikonin in A549 cells occurs by necroptosis. a Cells were pretreated for 2 h in the presence or absence of Nec‑1 (100 μM), Z‑VAD (20 μM), Z‑DEVD (20 µM), Z‑IETD (10 µM), or Z‑LEHD (20 µM) and then incubated with shikonin (3 or
Fig. 3 The anti‑tumor effect of shikonin on A549 cells by inducing necroptosis in vivo
Fig. 4 Shikonin‑induced autophagy in A549 cells. a Cells were treated with 3 or 6 µM shikonin for 3 h, and the levels of the indicated proteins were analyzed by western blotting
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