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Depletion of thymopoietin inhibits proliferation and induces cell cycle arrest/apoptosis in glioblastoma cells

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Academic year: 2020

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Figure

Fig. 1 Upregulation of TMPO mRNA in GBM was revealed by Oncomine database. The expression of the TMPO gene was extracted and analyzedfrom a the French Brain dataset, b the Liang Brain dataset, c the Murat Brain dataset, d the TCGA Brain dataset, e the Shai Brain dataset, f the SunBrain dataset, and g the Pomeroy Brain dataset shown as scatterplots
Fig. 2 Knockdown efficiency of TMPO by lentivirus infection in the GBM cells.TMPO-shRNA(S2) effectively decreased the protein expression of TMPO in U251 cells
Fig. 3 Downregulation of TMPO inhibited the proliferation of GBM cells. a, b Cell proliferation in U251 and U87 cells after TMPO-shRNA infection wasdetermined by MTT assay, respectively
Fig. 4 Downregulation of TMPO arrested the cell cycle of U251 cells. a, d The cell cycle distribution determined by flow cytometer
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