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Preparation, characterization, in vitro and in vivo anti-tumor effect of thalidomide nanoparticles on lung cancer

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Table 1 characterization of thalidomide nanoparticles
Figure 1 Physicochemical characterization of THA-NPs and fluorescent images of A549 cells treated with different drugs.Notes: (A) TeM image of Tha-NPs; (B) Tha-NP particle size distribution; (C) zeta potential of Tha-NPs; and (D) fluorescent images of A549 cells treated with normal saline for 2 h, (E) treated with a mixture of c6 and MPeg-Pcl for 2 h, (F) treated with c6-loaded MPeg-Pcl NPs for 2 h.Abbreviations: Tha-NPs, nanoparticles loaded with thalidomide; TeM, transmission electron microscopy; c6, coumarin-6; MPeg-Pcl, methoxy poly(ethylene glycol)-poly(ε-caprolactone).
Figure 2 cytotoxicity studies on a549 cells after different treatments and in vitro drug release of Tha-NPs and free Tha.Notes: (A) In vitro cell viability of free Tha and Tha-NPs in a549 cells after 24 h of incubation; (B) in vitro cell viability of blank
Figure 3 Tumor growth inhibition of Tha-NPs in subcutaneous a549 model and corresponding 18F-FDg PeT images of mice after 1 full day of treatment.Notes: (A) suppression of subcutaneous tumor growth by Tha-NPs in mice; (B) survival curve of mice in each gro
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