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Advances in the management of glioblastoma: the role of temozolomide and MGMT testing

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Figure

Figure 1 MTiC, the active metabolite of TMZ, adds a methyl group to guanine which causes a base pair mismatch
Figure 2 The bisulfite reaction is the first step in detection of MGMT methylation status for both gel-based and real-time polymerase chain reaction.Abbreviation: MGMT, O6-methylguanine-DNA methyltransferase.

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