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Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans

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Academic year: 2020

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Figure 1 daf-16/FoxOFoxOunique N-terminal exons (green and orange) and Forkhead domains(yellow) that correspond to DAF-16/FoxO protein domains in isoforms and isoform-specific mutations
Figure 3 Effects of16f daf-16a- and daf--specific mutations, RNAi, and single-copy transgenic rescues on daf-2/IGFRlife span
Figure 4 Effects ofanimals lacking a germline. (A and B)Effects ofmutations on life spans of germline-ablatedglp-1(e2141)required for daf-16a- and daf-16f-specific mutations and RNAi on life span in daf-16a (A) and daf-16f (B) animals
Figure 5 DAF-16A and DAF-16F target
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