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Unrelated

Cord Blood

Banks/Registries

Annual Report 2007, 9

th

Edition

An annual publication in conjunction with the European Blood and Marrow Transplantation

(EBMT) Group

(2)

__________________________________________________________________________

Page

Table of contents 1

Introduction and publication rights 2

List of participating cord blood banks and registries 4

Cumulative total of all responses 7

Figure 1: Number of participating cord blood banks/registries 11 Figure 2: Number of cord blood units available for transplantation 11 Figure 3: Number of cord blood units provided for unrelated transplantation 12 Figure 4: Number of cord blood units provided for multi-cord transplantation 12 Figure 5: Degree of matching of the cord blood units provided for children 13 Figure 6: Degree of matching of the cord blood units provided for adults 13 Figure 7: Degree of matching of the cord blood units provided over the years 14 Table 1: Comparison of the degree of matching (A, B serol. split, DRB1

allele level) of the cord blood units provided over the years 14 Table 2: Cord blood units provided for national and international patients 15 Figure 8: Percentage cord blood units provided for national and international patients 15 Table 3: Cord blood units provided for transplantation by the continents 15 Figure 9: Number cord blood units provided for national and international patients 16 Table 4: Distribution of cord blood units from continents to different countries 17 Table 5: Cord blood units provided to and by the continents 19

Figure 10: Cord blood units provided to continents 19

Figure 11: Cord blood units provided by continents 19

Table 6: Percentage of cord blood units provided for transplantation

in relation to the number of cord blood units present per country 20 Table 7: Percentage of cord blood units exported in relation to the

number of cord blood units present per country 21 Figure 12: Size of the cord blood bank versus the number of cord blood units

provided for transplantation 22

Figure 13: Size of the cord blood bank versus the number of cord blood units

provided for transplantation 22

Figure 14: Total Nucleated Cell counts of units used for multi-cord transplantation 23 Figure 15: Total Nucleated Cell counts of units used for single transplantation 23

Analysis of all responses 24

Appendix 1 25

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SHARE GOALS

The World Marrow Donor Association (WMDA) is an international collaboration effort of organisations and individuals involved in hematopoietic stem cell donation and

transplantation. The mission of the WMDA is:

The World Marrow Donor Association (WMDA) fosters international collaboration to facilitate the exchange of high quality hematopoietic stem cells for clinical transplantation worldwide and to promote the interests of donors.

One of the annual projects of the WMDA is to collect the number of unrelated stem cell products provided by the unrelated stem cell donor registries and cord blood banks (CBB) worldwide. WMDA is collecting these data from 1999 and is proud to send out the ninth edition of the Cord Blood Banks/Registries Annual Report. WMDA Office thanks the participating organisations for sharing the data and Histogenetics for supporting this important project.

SHARE LIFE

Cord blood units are listed in the Bone Marrow Donors Worldwide or in the Netcord Virtual Office. A cord blood bank can provide his units through a registry or directly. Some cord blood banks have provided their units through a registry as well as directly. WMDA Office contacted 107 different cord blood banks worldwide:

- 83 CBBs provide their units via a registry - 13 CBBs provide their units directly

- 4 CBBs just started and did not participate in the survey

- 7 CBBs provide their units via one (or two) registry (ies) and directly

The major change for the year 2007 is that all Italian Cord Blood Banks have become part of the Italian BMDR & Cord Blood Bank Network. The difference between 2006 and 2007 is that the Italian Banks are listed together in stead of separately.

Four CBB participated for the first time. The WMDA Office received the questionnaire back from Asiacord (Seoul Cord Blood Bank), CordMX CNTS Mexico, Swedcord and Gift of Life Bone Marrow Foundation. Welcome to this project and we hope to establish a long relationship.

The WMDA website shows information specified per CBB (number of units stored, mother health questionnaire, IDM testing and courier incidents). For further details you can visit: www.worldmarrow.org

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__________________________________________________________________________

SHARE QUALITY

Netcord-FACT developed an accreditation program for cord blood banks. At the moment 15 CBB are accredited by Netcord-FACT. In appendix 1 you can see which cord blood banks are accredited by Netcord-FACT.

SHARE KNOWLEDGE

The number of unrelated cord blood units provided per year increases annually. All CBBs together reported that 2,743 cord blood products were provided for transplantation in 2007. Of 79% of the cord blood units information is available whether the unit have been used for single or double transplantation:

- 823 cord blood units have been used four double transplantation - 1,286 cord blood units have been used for single transplantation - 66 cord blood units have been used for subsequent transplantation - 568 cord blood units no information have been provided

Over 40% of these products involved a transplant from a donor in a country that was different to the patient’s. The products were shipped to 43 different countries. SHARE EXPERIENCE

The number of cord blood products increases annually. At the end of 2007 a new WMDA Working Group has been established. The Cord Blood WG is chaired by Kathy Welte (NMDP, USA). If you want to join this working group, you can contact the WMDA Office. SHARE INFORMATION

Stem Cell Donor Registries and Cord Blood Banks have voluntarily contributed data on the understanding that publications may result. Each registry is free to use the data for its own internal use, but any use of the data for publication must receive prior approval of the WMDA Board or it designee.

GET IN TOUCH WITH US

Information on the WMDA is available on: http://www.worldmarrow.org or can be asked by e-mail: wmda@europdonor.nl

Machteld Oudshoorn, Lydia Foeken-van Goozen

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COUNTRY NAME

Argentina Argentine CPH Donors Registry

Australia AusCord

Austria Austrian Cord Blood Registry

Belgium Marrow Donor Program Belgium

Belgium Leuvencord

Brazil BrasilCord/REDOME

Canada Victoria Angel Registry of Hope

China Shandong Umbilical Cord Blood Bank

Cyprus The Cyprus Rotary Cord Blood Registry (CYCORD) Czech Republic Czech Stem Cell Registry

Finland Finnish Cord Blood Bank

France France Greffe de Moelle

Germany ZKRD Zentrales Knochenmarkspender Register

Germany José Carreras Stammzellbank

Greece Hellenic Cord Blood Bank (HCBB)

Israel Hadassah Unrelated Donor and Cord Blood Registry

Israel Sheba Cord Blood Bank

Italy Italian BMDR and Cord Blood Bank Network

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__________________________________________________________________________

COUNTRY NAME

Japan Tokyo Cord Blood Bank

Korea KoreaCORD

Korea Seoul Cord Blood Bank

Korea Catholic Hematopoietic Stem Cell Bank

Mexico Mexican Cord Blood Bank and Registry BACECU

Mexico CordMX CNTS Mexico

Netherlands, The Europdonor Foundation/EuroCord Netherlands Poland Unrelated Bone Marrow Donor & Cord Blood Registry Poland Central Bone Marrow & CB Registry POLTRANSPLANT

Singapore* Singapore Cord Blood Bank

Slovakia Eurocord Slovakia

Spain REDMO - Spanish Cord Blood Registry

Sweden SWEDCORD – Swedish National Cord Blood Bank

Switzerland Swiss Blood Stem Cells

Taiwan Buddhist Tzu Chi Stem Cells Center (BTCSCC)

Taiwan Bionet Babybanks Corp.

Taiwan Healthbanks Biotec Co. Ltd.

Taiwan* StemCyte Taiwan National Cord Blood Center

Thailand Thai National Cord Blood Bank

Turkey Ankara Cord Blood Registry

United Kingdom London Cord Blood Bank

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COUNTRY NAME

United States of America Celgene Cord Blood Bank Cedar Knolls United States of America* University of Colorado Cord Blood Bank United States of America* Elie Katz Umbilical Cord Blood Program

United States of America Michigan Community Blood Centers Cord Blood Bank United States of America National Marrow Donor Program (NMDP)

Unites States of America New York Blood Center – National Cord Blood Program United States of America* St. Louis Cord Blood Bank

United States of America* StemCyte Inc.

United States of America Gift of Life Bone Marrow Foundation

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__________________________________________________________________________

GENERAL INFORMATION

1. Total number of cord blood units in cord blood registry/bank available for

transplantation on 31st December 2007 406,496

2. Number of new cord blood units added during 2007 available for transplantation 74,293 3. Number of cord blood units deleted during 2007 for other reasons than transplantation 5,350

SEARCH REQUESTS DURING 2007

4. Number of searches for cord blood units requested for unrelated national patients 16,628 5. Number of searches for cord blood units requested for unrelated international patients 61,832

6. DNA SAMPLES REQUESTED FOR CONFIRMATORY TYPING IN 2007

Samples from your cord blood registry/bank shipped on request to transplant centres 1,335 DNA typing performed by your own cord blood bank/registry on request of transplant centres 4,885

7. CORD BLOOD UNITS SHIPPED IN 2007

The total number of cord blood units provided for transplantation in 2007 2,743 The total number of cord blood units actually transplanted in 2007 2,551 The total number of cord blood units that have been used for expansion 1 The total number of cord blood units that have been used for other purposes (NK cells) 6

8. UNRELATED UNITS PROVIDED FOR CHILDREN (≤≤≤≤ 15 years)

Cord blood units provided for children for mono transplantation

Degree of matching (A, B serological split level, DRB1 allele) first subse- no Number of matched/mismatched cord blood units provided during 2007 mono quent info 0 antigen mismatched units 143 5 50 1 antigen mismatched units 348 15 93 2 antigens mismatched units 224 20 38 3 or more antigens mismatched units 3 0 5 no information about the degree of matching 11 0 26

TOTAL 729 40 212

9. Multi cord blood units provided for children (all units provided by the same bank)

Degree of matching (A, B serological split level, DRB1 allele) first second Number of matched/mismatched cord blood units provided during 2007 unit unit

0 antigen mismatched units 13 5

1 antigen mismatched units 35 33

2 antigens mismatched units 25 39

3 or more antigens mismatched units 1 1

no information about the degree of matching 20 20

TOTAL 94 98

ANNUAL REPORT QUESTIONNAIRE 2007 CUMULATIVE TOTAL OF ALL RESPONSES

(9)

10 Multi cord blood units provided for children (units provided by different banks)

Degree of matching (A, B serological split level, DRB1 allele) Number of matched/mismatched cord blood units provided during 2007

0 antigen mismatched units 3 1 antigen mismatched units 11 2 antigens mismatched units 16 3 or more antigens mismatched units 1 no information about the degree of matching 2

TOTAL 33

UNRELATED UNITS PROVIDED FOR ADULTS (> 15 years old)

11 Cord blood units provided for adults for mono transplantation

Degree of matching (A, B serological split level, DRB1 allele) first subse- no

Number of matched/mismatched cord blood units provided during 2007 mono quent info

0 antigen mismatched units 32 0 20

1 antigen mismatched units 177 4 85 2 antigens mismatched units 318 18 120 3 or more antigens mismatched units 22 4 7 no information about the degree of matching 8 0 7

TOTAL 557 26 239

12 Multi cord blood units provided for adults (all units provided by the same bank)

Degree of matching (A, B serological split level, DRB1 allele) first additional

Number of matched/mismatched cord blood units provided during 2007 unit Units

0 antigen mismatched units 14 7 1 antigen mismatched units 83 64 2 antigens mismatched units 119 144 3 or more antigens mismatched units 3 6 no information about the degree of matching 6 6

TOTAL 225 227

13 Multi cord blood units provided for adults (units provided by different banks)

Degree of matching (A, B serological split level, DRB1 allele)

Number of matched/mismatched cord blood units provided during 2007

0 antigen mismatched units 4 1 antigen mismatched units 50 2 antigens mismatched units 77 3 or more antigens mismatched units 6 no information about the degree of matching 9

TOTAL 146

* Of 117 units no data are known about the degree of HLA matching and the age of the patient

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__________________________________________________________________________

CANCELLATIONS DURING 2007

14 Number of cancellations by cord blood registry/bank after the cord blood unit had been chosen (total of national and international patients) 168 15 Number of cancellations by national transplant centres after the cord blood unit

had been chosen (i.e. for patient related reasons). 234

16 Number of cancellations by international transplant centres after the cord blood unit

had been chosen (i.e. for patient related reasons). 97

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CORD BLOOD UNITS PROVIDED FOR TRANSPLANTATION TO FOLLOWING

Number of Number of

COUNTRIES Units Recipients

1 ARGENTINA 5 5 2 AUSTRALIA 80 64 3 AUSTRIA 4 3 4 BELGIUM 16 16 5 BRAZIL 68 66 6 CANADA 75 70 7 CHILE 19 17 8 CHINA 17 14

9 CHINA HONG KONG 4 4

10 COLOMBIA 24 19 11 CZECH REPUBLIC 6 5 12 ECUADOR 3 3 13 EGYPT 1 1 14 FINLAND 9 7 15 FRANCE 336 290 16 GERMANY 17 15 17 GREECE 32 22 18 HUNGARY 4 4 19 INDIA 2 2 20 ISRAEL 24 21 21 ITALY 92 89 22 JAPAN 148 148 23 JORDAN 2 2 24 KOREA 74 46 25 MALAYSIA 8 7 26 MEXICO 48 41 27 NETHERLANDS 32 31 28 NEW ZEALAND 13 11 29 NORWAY 4 3 30 PORTUGAL 14 13 31 SAUDI ARABIA 26 24 32 SINGAPORE 24 20 33 SLOVENIA 1 1 34 SOUTH AFRICA 3 3 35 SPAIN 114 114 36 SWEDEN 19 19 37 SWITZERLAND 12 8 38 TAIWAN 42 34 39 THAILAND 1 1 40 TURKEY 15 15 41 UNITED KINGDOM 85 80

42 UNITED STATES OF AMERICA 1,102 940

43 VENEZUELA 1 1

UNKNOWN 117 N.A.

TOTAL 2,743 2,299*

* this figure may be less; not all registries obtained information whether the unit was used for single or double cord blood transplantation

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_________________________________________________________________________ 19 28 33 36 40 40 49 47 49 0 10 20 30 40 50 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year

Figure 1: Number of cord blood banks/registries

N um be r of p ar tic ip at in g co rd bl oo d re gi st ri es /b an ks 44 70 105 136 181 229 256 292 406 0 50 100 150 200 250 300 350 400 450 N um be r of c or d bl oo d un its (x th ou sa nd ) 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year

Figure 2: Total Number of cord blood units available for transplantation

© WMDA 2007

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368 390 540 617 963 1,126 1,791 2,086 2,743 0 250 500 750 1,000 1,250 1,500 1,750 2,000 2,250 2,500 2,750 N um be r of c or d bl oo d un its 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year units provided

Figure 3: Number of cord blood units provided for unrelated transplantation 96 190 432 596 823 0 100 200 300 400 500 600 700 800 900 N um be r of c or d bl oo d un its p ro vi de d 2003 2004 2005 2006 2007 Year

Figure 4: Number of cord blood units provided for multicord transplantation

Remark: 2004: no information available of 29% of the units provided 2005: no information available of 45% of the units provided 2006: no information available of 41% of the units provided 2007: no information available of 21% of the units provided

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_________________________________________________________________________ 219 535 362 11 79 0 100 200 300 400 500 600 N um be r of c or d bl oo d un its

Figure 5: Degree of matching of the cord blood units

provided for children (N=1,206 units)* 0 mismatched 1 mismatched 2 mismatched 3 or more not specified 77 463 796 48 36 0 100 200 300 400 500 600 700 800 N um be r of c or d bl oo d un its

Figure 6:Degree of matching of the cord blood units

provided for adults (N=1,420 units)*

0 mismatched 1 mismatched 2 mismatched 3 or more not specified © WMDA 2007 © WMDA 2007

*From 117 cord blood units no information is available whether the unit has been used for child or adult patient

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Table 1: Comparison of the degree of matching of cord blood units provided over the years

Degree of matching 1999 2000 2001 2002 2003 2004 2005 2006 2007 0 mismatched 10.4% 12.1% 16.3% 14.2% 12.8% 14.2% 13.2% 11.2% 11.8% 1 mismatched 46.6% 41.8% 41.0% 38.3% 41.6% 41.1% 38.1% 38.0% 39.7% 2 mismatched 40.6% 41.8% 40.2% 40.6% 42.4% 42.0% 43.7% 46.5% 46.1%

3 or more 2.5% 4.2% 2.6% 6.8% 3.2% 2.7% 5.0% 4.2% 2.4%

Remark: units for which the degree of matching was not specified are excluded from this table

Figure 7: Degree of matching of the cord blood units provided over the years

0 200 400 600 800 1000 1200 1400 1999 2000 2001 2002 2003 2004 2005 2006 2007 Years N um be r of c or d bl oo d un its

0 mismatched 1 mismatched 2 mismatched 3 or more mismatched © WMDA 2007

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_________________________________________________________________________

Table 2: Cord blood units provided for international and national patients

PATIENTS YE A R 19 99 20 00 20 01 20 02 20 03 20 04 20 05 20 06 20 07 TOTAL INTERNATIONAL 129 146 192 175 284 387 652 829 1,098 3,892 NATIONAL 239 244 348 390 679 739 1,139 1,246 1,528 6,552 NOT SPECIFIED 0 0 0 52 0 0 0 0 117 169 TOTAL 368 390 540 617 963 1,126 1,791 2,075 2,743 10,613

Figure 8: Percentage of cord blood units provided for national and international patients

35.1 37.4 35.6 28.4 29.5 34.4 36.4 40.0 40.0 64.9 62.6 64.4 63.2 70.5 65.6 63.6 60.0 55.7 0 10 20 30 40 50 60 70 80 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year P er ce nt ag e

Provided Internationally Provided Nationally

Table 3: Cord blood units provided for transplantation by the continents

UNITS FROM YE A R 19 99 20 00 20 01 20 02 20 03 20 04 20 05 20 06 20 07 TOTAL ASIA 2 37 85 86 139 194 346 286 318 1,493 AUSTRALIA 5 20 22 14 19 35 45 96 158 414 EUROPE 116 141 191 168 189 311 467 629 744 2,956 NORTH AMERICA 245 192 242 297 616 586 925 1,051 1,456 5,610 SOUTH AMERICA 0 0 0 0 0 0 8 12 67 87 AFRICA 0 0 0 0 0 0 0 0 0 0 NOT SPECIFIED 0 0 0 52 0 0 0 1 0 53 TOTAL 368 390 540 617 963 1,126 1,791 2,075 2,743 10,613 © WMDA 2007 © WMDA 2007 © WMDA 2007

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Figure 9: Number of cord blood units provided for national and international patients

129 146 192 175 284 387 652 829 1,098 239 244 348 390 679 739 1,139 1,246 1,528 0 500 1000 1500 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year N um be r of C or d B lo od u ni ts

Provided internationally Provided nationally

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__ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ W O R LD M A R R O W D O N O R A S S O C IA TI O N C O R D B LO O D B A N K S /R E G IS TR IE S A N N U A L R E P O R T 20 07 P ag e 17 Tabl e 4: D is tr ib ut io n of c or d bl oo d un its fr om s pe ci fie d pe r co un tr y TO AR GE NT IN A BR AZ IL CH ILE CO LO MB IA EC UA DO R ME XIC O VE NE ZU ELA AU ST RA LIA NE W Z EA LA ND CA NA DA UN IT ED S TA TE S AU ST RIA BE LG IU M CY PR US CZ EC H R EP UB LIC DE NM AR K FIN LA ND FR AN CE GE RM AN Y GR EE CE HU NG AR Y IR ELA ND IT ALY NE TH ER LA ND S NO RW AY PO LA ND PO RT UG AL RU SS IA SLO VA KIA SLO VE NIA SP AIN SW ED EN SW IT ZE RLA ND TU RK EY UN IT ED K IN GD OM CH IN A CH IN A H ON G K ON G EG YP T IN DIA IS RA EL JA PA N JO RD AN KO RE A MA LA YS IA SA UD I A RA BIA SIN GA PO RE TA IW AN TH AIL AN D SO UT H A FR IC A UN KN OW N TO TA LS 16 16 2 1 4 7 1 14 8 14 9 74 74 6 6 1 1 2 4 1 1 1 4 1 6 7 37 66 0 0 54 3 4 29 1 14 1 7 7 6 1 2 1 24 3 1 15 8 0 0 1 1 1 1 4 28 5 13 1 2 2 6 3 2 3 4 2 5 3 1 1 89 0 0 B LI C 1 2 0 5 1 9 1 1 2 2 1 1 5 26 1 2 1 12 0 4 4 6 4 10 3 1 1 2 1 19 5 3 2 1 8 32 3 2 16 3 3 17 4 4 1 1 2 12 1 11 5 5 5 3 2 1 2 31 1 2 1 12 2 2 24 4 1 2 3 1 3 6 10 3 S 1 1 2 3 1 1 6 0 2 2 1 20 0 0 0 0 1 1 22 1 2 30 3 4 1 9 1 3 57 2 2 9 1 3 15 2 0 0 D 2 2 5 2 11 0 0 D O M 1 2 21 5 4 1 1 8 43 a 0 0 30 30 3 34 37 0 0 1 1 30 18 19 14 1 20 6 45 89 9 2 4 1 3 10 9 3 16 1 20 6 2 6 1 31 4 1 19 1 9 1 2 26 10 5 1 2 11 7 1, 45 5 5 68 19 24 3 48 1 80 13 75 1, 10 2 4 16 0 6 0 9 33 6 17 32 4 0 92 32 4 0 14 0 0 1 11 4 19 12 15 85 17 4 1 2 24 14 8 2 74 8 26 24 42 1 3 11 7 2, 74 3 © W M D A 2 00 7

(19)

__ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ W O R LD M A R R O W D O N O R A S S O C IA TI O N C O R D B LO O D B A N K S /R E G IS TR IE S A N N U A L R E P O R T 20 07 P ag e 18 Ta bl e 4: D is tr ib ut io n of c or d bl oo d un its fr om s pe ci fie d pe r co un tr y TO AR GE NTI NA AU ST RA LIA AU ST RIA BE LG IU M BR AZ IL CA NA DA CH ILE CH IN A CH IN A H ON G K ON G CO LO MB IA CY PR US CZE CH R EP UB LIC DE NM AR K EG YP T EC UA DO R FIN LA ND FR AN CE GE RM AN Y GR EE CE HU NG AR Y IN DIA IR ELA ND IS RA EL ITA LY JA PA N JO RD AN KO RE A MA LA YS IA ME XIC O NE TH ER LA ND S NE W Z EA LA ND NO RW AY PO LA ND PO RTU GA L RU SS IA SA UD I A RA BIA SIN GA PO RE SLO VA KIA SLO VE NIA SO UTH A FR I C A SP AIN SW ED EN SW IT ZE RLA ND TA IW AN TH AIL AN D TU RK EY UN ITE D K IN GD OM UN ITE D S TA TE S VE NE ZU ELA UN KN OW N TO TA LS 0 0 54 1 4 14 1 3 7 7 3 1 6 1 2 1 24 29 15 8 0 0 1 1 5 1 4 13 1 2 2 1 6 3 1 2 1 3 4 2 5 3 28 89 30 30 0 1 1 16 16 0 0 1 0 5 1 2 9 1 1 2 2 1 2 1 5 1 12 0 4 1 4 6 1 4 10 3 1 1 2 26 19 5 2 3 8 3 2 16 3 3 1 17 4 1 4 1 1 2 12 32 11 5 5 5 1 4 2 7 1 1 2 3 2 2 1 12 2 2 24 4 1 2 3 1 3 6 31 10 3 14 8 1 14 9 74 74 3 34 37 1 1 2 1 1 6 2 1 0 2 3 20 0 0 6 6 0 0 1 1 1 2 30 3 4 1 1 3 9 1 3 57 2 2 9 22 15 2 0 0 2 5 2 2 11 1 2 1 4 1 6 1 7 1 37 1 4 66 0 0 0 0 1 2 5 4 1 1 8 21 43 20 2 4 30 45 18 19 1 1 3 10 9 3 16 1 9 20 1 2 14 6 6 2 6 26 10 1 2 31 4 5 1 1 19 89 9 1 11 7 1, 45 5 5 80 4 16 68 75 19 17 4 24 0 6 0 1 3 9 33 6 17 32 4 2 0 24 92 14 8 2 74 8 48 32 13 4 0 14 0 26 24 0 1 3 11 4 19 12 42 1 15 85 1, 10 2 1 11 7 2, 74 3

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_________________________________________________________________________

Table 5: Cord blood units provided to and by continents

FROM TO A FR IC A A S IA A U S TR A LI A E U R O P E N O R TH A M E R IC A S O U TH A M E R IC A U N K N O W N TO TA L AFRICA 0 0 0 0 0 0 0 0 ASIA 0 304 2 4 8 0 0 318 AUSTRALIA 0 4 57 64 33 0 0 158 EUROPE 1 10 8 515 191 19 0 744 NORTH AMERICA 2 55 26 229 945 82 117 1,456 SOUTH AMERICA 0 0 0 0 0 67 0 67 TOTAL 3 373 93 812 1,177 168 117 2,743 14% 3% 30% 43% 4% 0.1% 6% AFRICA ASIA AUSTRALIA EUROPE NORTH AMERICA SOUTH AMERICA UNKNOWN TO

Figure 10: Cord blood units provided to continents

12% 6% 27% 53% 2.4% ASIA AUSTRALIA EUROPE NORTH AMERICA SOUTH AMERICA BY

Figure 11: Cord blood units provided by continents

© WMDA 2007

© WMDA 2007

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Table 6: Percentage of cord blood units provided for transplantation in relation to the number of cord blood units present

Cord blood units

COUNTRY PROVIDED AVAILABLE %

Mexico CNTS 37 974 3.799% France 195 6,164 3.164% Japan (Tokyo) 149 5,238 2.845% Brazil 30 1,983 1.513% USA-NMDP Network 882 72,950 1.209% USA-New York 416 36,002 1.155% Belgium 70 6,423 1.090% Greece 5 530 0.943% Australia 158 18,094 0.873% Germany Duesseldorf 94 12,923 0.727%

Italy Cord Blood Network 103 16,402 0.628%

Switzerland 11 1,882 0.584% Netherlands 20 3,505 0.571% Israel Sheba 7 1,326 0.528% Spain 152 28,801 0.528% United Kingdom 43 9,102 0.472% Korea KMDP 60 14,307 0.419% USA-Michigan 9 2,318 0.388% Germany 21 6,241 0.336% Czech Republic 9 2,792 0.322% China Shandong 16 6,048 0.265% Belgium Leuven 19 7,582 0.251% Taiwan BTCSCC/CBB 7 5,352 0.131% USA-Gift of Life 1 772 0.130% Taiwan Healthbanks 2 1,734 0.115% USA-Celgene 4 4,079 0.098% Finland 2 2,805 0.071% USA-CRIR 6 10,636 0.056% Korea Catholic 1 1,800 0.056% Taiwan Babybanks 7 13,941 0.050%

Korea Seoul Cord Blood Bank 13 83,661 0.016%

Israel Hadassah 0 3,082 0.000% Cyprus 0 502 0.000% Thailand 0 322 0.000% Poland Poltransplant 0 303 0.000% Slovakia 0 216 0.000% Argentina 0 166 0.000% Austria 0 155 0.000% Mexico BACECU 0 145 0.000% Sweden 0 100 0.000% Canada Victoria 0 45 0.000% Poland 0 41 0.000% Turkey 0 16 0.000% TOTAL 2,549 391,460 0.651%

These Cord Blood Banks provide also units through a registry.

USA-Colorado* 57 5,606 1.017% Taiwan Stemcyte* 50 10,061 0.497% USA-St. Louis* 47 16,248 0.289% Singapore* 6 2,218 0.271% USA-Stemcyte 32 12,854 0.249% USA-Elie Katz* 2 3,363 0.059% TOTAL 194 50,350 0.385%

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_________________________________________________________________________

Table 7: Percentage of cord blood units exported in relation to the number of cord blood units present

Cord blood units

COUNTRY PROVIDED AVAILABLE %

France 76 6,164 1.233% Belgium 66 6,423 1.028% Germany Düsseldorf 92 12,923 0.712% Australia 104 18,094 0.575% Netherlands 20 3,505 0.571% USA-New York 197 36,002 0.547%

Italy Cord Blood Bank Network 79 16,402 0.482%

Switzerland 9 1,882 0.478% United Kingdom 35 9,102 0.385% Spain 95 28,801 0.330% Czech Republic 9 2,792 0.322% Germany 20 6,241 0.320% Mexico CNTS 3 974 0.308% USA-NMDP Network 189 72,950 0.259% Belgium Leuven 18 7,582 0.237% Israel Sheba 3 1,326 0.226%

USA Gift of Life 1 772 0.130%

USA-Michigan 3 2,318 0.129% Taiwan BTCSCC/CBB 4 5,352 0.075% USA Celgene 3 4,079 0.074% Taiwan Healthbanks 1 1,734 0.058% Finland 1 2,805 0.036% Japan (Tokyo) 1 5,238 0.019% Taiwan Bionet 1 13,941 0.007% Korea Seoul 0 83,661 0.000% Korea KMDP 0 14,307 0.000% USA-CRIR 0 10,636 0.000% China Shandong 0 6,048 0.000% Israel Hadassah 0 3,082 0.000% Brazil 0 1,983 0.000% Korea Catholic 0 1,800 0.000% Greece 0 530 0.000% Cyprus 0 502 0.000% Thailand 0 322 0.000% Poland Poltransplant 0 303 0.000% Slovakia 0 216 0.000% Argentina 0 166 0.000% Austria 0 155 0.000% Mexico BACECU 0 145 0.000% Sweden 0 100 0.000% Canada Victoria 0 45 0.000% Poland 0 41 0.000% Turkey 0 16 0.000% TOTAL 1,030 391,460 0.263%

These cord blood banks also provide through a registry.

USA-Stemcyte* 24 12,854 0.187% USA-Colorado* 19 5,606 0.339% Taiwan Stemcyte* 23 10,061 0.229% USA St. Louis* 2 16,248 0.012% USA-Paramus* 0 3,363 0.000% Singapore* 0 2,218 0.000% TOTAL 68 50,350 0.135% © WMDA 2007

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Figure 12: Size of the cord blood bank versus the number (cord blood banks/registry < 4,000 units)

0 5 10 15 20 25 30 35 40

Size of the Cord Blood Bank/Registry

N um be r of c or d bl oo d un its p ro vi de d

Number of Cord Blood Units Provided

4000 The Netherlands

0

Brazil

Mexico

of cord blood units provided for transplantation

Figure 13: Size of the cord blood bank versus the number of cord blood units provided for transplantation (cord blood bank/registry >4,000 units)

0 100 200 300 400 500 600 700 800 900

Size of the Cord Blood Bank/Registry

N um be r of c or d bl oo d un its p ro vi de d

Number of Cord Blood Units Provided France New York NMDP Tokyo 4000 70,000 © WMDA 2007

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_________________________________________________________________________ Figure 14: Total Nucleated Cell (TNC) counts of units

provided for multicord transplantation

0 10 20 30 40 50 30 50 70 90 150 210 270 330 390

Total Nucleated Cell Count (x10E7)

N um be r of u ni ts children adults TNC median unit children: 132x10E7

TNC average unit children: 144x10E7 TNC median unit adult: 170x10E7 TNC average unit adult: 177x10E7

Figure 15: Total Nucleated Cell (TNC) counts of the cord blood units provided for single transplantation

0 10 20 30 40 50 60 70 80 90 30 60 90 120 150 180 210 240 270 300 330 360 390 N um be r of u ni ts children adults TNC median unit children: 132x10E7

TNC average unit children: 145x10E7 TNC median unit adult: 185x10E7 TNC average unit adult: 196x10E7

Total Nucleated Cell Count (x10E7)

© WMDA 2007 © WMDA 2007

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ANALYSIS OF ALL RESPONSES

REGISTRY STATISTICS ON DECEMBER 31st, 2007

Total number of questionnaires sent 49

Total number of registries responding 49

Percentage of responses 100%

Total number of cord blood units available on January 1st, 2007 324,110

Units added in 2007 74,293

Units deleted in 2007 5,350

Units used for transplantation in 2007 2,743

Total number of cord blood units on December 31st, 2007 406,496

Cord blood units available on January 1st, 2007 324,110=100%

Percentage of new units added in 2007 22.9%

Percentage of units deleted in 2007 -1.7%

Percentage of units used for transplantation in 2007 -0.85%

SEARCH REQUESTS DURING 2007

Total number of searches for cord blood units 78,460=100% Number and percentage of searches for national patients 16,628 21.2% Number and percentage of searches for international patients 61,832 78.8%

Number of DNA samples shipped on request to transplant centres 1,385 Number of DNA typings performed on request by transplant centres 4,885

CORD BLOOD UNITS PROVIDED FOR TRANSPLANTATION DURING 2007

Total number of cord blood units provided 2,743=100% Number and percentage of units provided for national patients 1,528 55.7% Number and percentage of units provided for international patients 1.098 40.0% Number and percentage of units provided no information recorded 117 4.3%

Percentage of transplantations in relation to search request 3.4% Percentage of transplantations in relation to the number of units available (average) 0.7% Percentage of cord blood units used for transplantation in relation to DNA

samples provided/HLA typed 43.7%

DEGREE OF MATCHING (A, B serological split level, DRB1 allele)

Total number of cord blood units matched 2,743=100% 0 antigen mismatched units 296 10.8% 1 antigen mismatched units 998 36.4% 2 antigens mismatched units 1,158 42.2% 3 or more antigens mismatched units 59 2.2% Not specified 232 8.5%

CORD BLOOD UNITS PROVIDED

Total number of units provided for 2,743=100%

adult patients (> 15 years old) 1,206 44.0%

children (≤15 years old) 1,420 51.7%

Unknown 117 4.3%

CANCELLATIONS DURING 2007

Cancellations by cord blood registries/banks 168

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_________________________________________________________________________

APPENDIX 1

Country Name of Cord Blood Banks active in your Registry Started Inventory Whole

Blood Number of CBU accredited? since units reduced volume

(year)

1 Argentina Argentine National Cord Blood Bank 2007 166 0 166 No 2 Australia Queensland Cord Blood Bank at the Mater 1998 3,179 0 3,179 TGA

3 Australia Sydney Cord Blood Bank 1995 9,536 66 9,470 NetCord-FACT 4 Australia BMDI Cord Blood Bank (Melbourne) 1996 5,379 0 5,379 NetCord-FACT 5 Austria Austrian Cord Blood Registry ?? 155 0 155 No

6 Belgium Navelstrengbloedbank Rode Kruis-Vlaanderen 2001 1,400 0 1,400 No 7 Belgium De Leuvense Navelstrengbloedbank 1997 7,582 484 7,098 Pending 8 Belgium Banque de sang de cordon umbilical Liege 1994 1,951 843 1,108 NetCord-FACT 9 Belgium Banque de sang de cordon Bruxelles (UCL) 1994 1,872 1,291 581 Belgium 10 Belgium Banque de sang de cordon Bruxelles (ULB) 1994 1,523 1,294 298 Belgium 11 Brazil Instituto Nacional de Cancer Rio de Janeiro 2002 881 0 881 No

12 Brazil HIAE Sao Paulo 2004 1,102 0 1,102 No

13 Brazil HC Campinas Sao Paulo 2007 NA NA NA No

14 Brazil HC Ribeirao Preto Sao Paulo 2007 NA NA NA No

15 Canada Alberta Cord Blood Bank 1997 1,153 No

16 Canada Victoria Angel Registry of Hope 2005 45 NA NA AABB

17 China Shan Dong Cord Blood Bank NA NA NA NA NA

18 China Beijing Cord Blood Bank NA NA NA NA NA

19 China ShangHai Cord Blood Bank NA NA NA NA NA

20 China GuangZhou cord blood bank. NA NA NA NA NA

21 Croatia Croatian Cord Blood Bank 2007 70 NA NA No 22 Cyprus CYCORD (The Cyprus Rotary Cord Blood Registry) 2005 502 No 23 Czech Republic Cord Blood Bank Czech Republic 1996 2,792 2,792 0 JCI

24 Finland Finnish Cord Blood Bank 1998 2,825 0 2,825 NetCord-FACT 25 France Besancon Cord Blood Bank 1999 3,009 1,433 1,576 NetCord-FACT 26 France Bordeaux Cord Blood Bank 1999 1,897 987 910 Pending 27 France Saint Louis Cord Blood Bank 1996 1,241 1,241 0 No 28 France Marseille Cord Blood Bank 2003 17 17 0 No

29 Germany Jose Carreras Stammzellbank Dusseldorf 1993 12,923 2,625 10,298 NetCord-FACT 30 Germany Cord Blood Bank Mannheim 1997 1,636 12 1,624 Pending 31 Germany DNS-BB Nabelschnurblutbank 2002 1,309 NA NA No 32 Germany Cord Blood Bank Freiburg 1999 1,080 0 1,080 No 33 Germany Bavarian Cord Blood Bank Munich 2000 2,216 0 2,216 Pending 34 Greece Hellenic Cord Blood Bank 2004 530 0 530 No

35 Israel Hadassah MDA Cord Blood Registry 2003 1,864 52 1,812 ISO 9001: 2000 36 Israel Hadassah Cord Blood Registry 1996 309 0 309 No

37 Israel Bedomaich Chayi 2006 1,060 93 967 No

38 Israel Sheba Cord Blood Bank 2001 1,326 0 1,326 Pending 39 Italy Milano Cord Blood Bank 1993 6,628 25% 75% NetCord-FACT 40 Italy Pavia Cord Blood Bank 1996 1,980 1,150 430 NetCord-FACT 41 Italy Padova Cord Blood Bank 1997 1,236 1,236 0 ISO 9001 42 Italy St. Eugenio Hospital Rome 1995 544 420 124 ISO 9001 43 Italy Pescara Cord Blood Bank 2007 375 0 375 ISO 9001

44 Italy Roma Centro 1994 629 NA NA ISO 9001

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Country Name of Cord Blood Banks active in your Registry Started Inventory Whole

Blood Number of CBU accredited? since units reduced volume

46 Italy Firenze Cord Blood Bank 1996 937 17 920 ISO 9001 47 Italy Liguria Cord Blood Bank Genova 2006 48 48 0 No

48 Italy Treviso Cord blood Bank 2004 744 NA NA No

49 Italy Unicatt Rome NA 375 NA NA NA

50 Italy Emilia Romagna Cord Blood Bank 2001 1,898 NO 100 Pending 51 Japan Tokyo Cord Blood Bank 1997 5,218 0 5,218 ISO 9001 52 Korea Medipost Cord Blood Bank 2000 7,866 0 7,866 No 53 Korea Allcord Seoul Metropolitan Public Cord Blood Bank 2006 3,600 0 3,600 No 54 Korea Cord Blood Bank iCord CHA Hospital 2003 2,283 0 2,283 Yes

55 Korea Samsung Cord Blood Bank 1997 99 0 99 No

56 Korea Busan Keung Nam Cord Blood Bank 2000 232 0 232 Yes 57 Korea Yeungnam University Hospital Cord Blood Bank 2003 11 0 11 No

58 Korea Green Cross Life Line 2003 216 0 216 No

59 Korea Catholic Hematopoietic Stem Cell Bank 2004 1,800 NA NA No 60 Korea Seoul Cord Blood Bank 2002 83,661 83,661 Asiacord 61 Mexico Bacecu Mexican Altruistic Cord Blood Bank 2002 145 46 99 National Gov.

62 Mexico CNTS NA NA NA NA NA

63 Netherlands Cord Blood Bank Leiden 1994 2,292 NAV NAV Pending 64 Netherlands Cord Blood Bank Nijmegen 1996 872 NAV NAV No 65 Poland Institute of Haematology and Transfusion Medicine 1998 41 41 0 No 66 Poland Jose Carreras Memorial Cord Blood Bank 2000 132 0 132 No 67 Poland Hematopoietic Progenitor Cel Processing Facility 1999 171 0 171 Yes 68 Singapore Singapore Cord Blood Bank 2005 2,218 NAV NAV No

69 Slovakia Eurocord Slovakia 1998 216 216 0 No

70 Spain Barcelona Cord Blood Bank 1997 7,715 NAV NAV Netcord-FACT 71 Spain Banco Cordon CTS Malaga 1997 8,686 NAV NAV Pending 72 Spain Banco Cordon CTS Madrid 1998 4,805 NAV NAV No 73 Spain Banco Cordon CTS Galicia 1998 4,879 NAV NAV Pending 74 Spain Banco Cordon CTS Valencia 1999 2,271 NAV NAV No 75 Spain Banco Cordon Hosp. Univ. Canarias 1999 445 NAV NAV No 76 Sweden Swedish National Cord Blood Bank "SWEDCORD" 2006 100 0 100 No 77 Switzerland Cord Blood Bank Basel 1998 1,211 0 1,211 Swiss GLP 78 Switzerland Cord Blood Bank Geneva 2000 671 0 671 ISO 9001: 2000 79 Taiwan Tzu Chi Registry 1998 5,352 NAV NAV National Gov. 80 Taiwan Taiwan Taipei Cord (TPCB) 1999 13,941 0 13,941 AABB, COLA

81 Taiwan Stemcyte 2003 10,061 NA NA AABB

82 Taiwan Healthbanks Cord Blood Center 2004 1,734 NAV NAV AABB/ISO/ASHI 83 Thailand Thai National Cord Blood Bank 2002 322 0 322 No

84 Turkey Ankara Cord Blood Bank 1998 16 NAV NAV No

85 United Kingdom London Cord Blood Bank 1996 8,864 0 0 NetCord-FACT 86 USA Celgene Cord Blood Bank 2004 4,079 0 4,079 AABB, ISO 87 USA Michigan Community Blood Centers' Cord Blood Bank 1999 2,318 0 2,318 AABB 88 USA University of Colorado Cord Blood Bank 1996 5,606 0 5,606 AABB 89 USA Cryobanks International Inc. 2000 9,544 0 9,544 AABB 90 USA The Elie Katz Umbilical Cord Blood Program 1996 3,363 0 3,363 No

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_________________________________________________________________________ Country Name of Cord Blood Banks active in your Registry Started Inventory

Whole

Blood Number of CBU accredited? since units reduced volume

91 USA New York Blood Center National Cord Blood Program 1993 36,002 1,585 34,317 NetCord-FACT 92 USA Ashley Ross Cord Blood Program 1999 2,239 0 2,239 AABB 93 USA Bonfils Cord Blood Services 1998 2,133 0 2,133 AABB 94 USA Carolinas Cord Blood Bank 2001 11,322 0 11,322 FACT

95 USA Cord:USE Orlando NA 1,491 0 1,491 No

96 USA Children Hospital of Orange County Cord Blood Bank 1999 2,129 0 2,129 No

97 USA Coriell - New Jersey Cord Blood Bank 0 AABB

98 USA Gift of Life Bone Marrow Foundation 2005 772 0 772 AABB 99 USA ITxM Cord Blood Service 1998 3,589 0 3,589 AABB 100 USA J.P. McCarthy Cord Stem Cell Bank 2001 1,198 0 1,198 No

101 USA LifeCord 1997 2,395 0 2,395 AABB/FACT

102 USA M.D. Anderson Cord Blood Bank NA 2,868 0 2,868 FACT 103 USA CBS: New Jersey Cord Blood Bank 2004 1,824 0 1,824 AABB 104 USA Puget Sound Blood Center 1998 1,547 0 1,547 AABB 105 USA St. Louis Cord Blood Bank 1996 16,248 0 16,248 AABB 106 USA StemCyte International Cord Blood Center 2001 12,854 0 803 AABB/FACT 107 USA Texas Cord Blood Bank 2005 1,302 0 1,302 AABB

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This annual report is sponsored by:

Acknowledgement:

WMDA Office would like to thank the cord blood registries and cord blood banks for providing their data.

References

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