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Original Article Panax notoginseng saponins improves the malignancy of chronic myeloid leukemia by inducing cell apoptosis and autophagy

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Figure

Figure 1. PNS reduced K562 cell viability in a time- and dose-dependent manner. A. MTT assay showed that 20 nM PNS suppressed K562 cell viability at 24, 48, 72 h, respectively
Figure 2. PNS led to apoptosis in K562 cells. A. Hoechst staining showed that PNS treatment significantly induced cated that cell apoptosis was increased by more than 35.6% after PNS treatment in K562 cells
Figure 3. PNS inactivates mTOR signaling and increases K562 cell autophagy. A. GFP-LC3 transfection assay indi-cated the enhanced cell autophagy in K562 cells after PNS treatment
Figure 4. PNS suppresses PI3K/Akt/mTOR signaling mainly by suppressing

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