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A novel capsid-modified oncolytic recombinant adenovirus type 5 for tumor-targeting gene therapy by intravenous route

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Figure

Figure 1: Diagrams of pIX-zipper-TRAIL configuration and Ad vector genomes depicting tumor targeting strategy
Figure 2: Chemical property analysis and biological activity of recombinant Ad vectors
Figure 3: Expression of TRAIL receptors on normal cells and cancer cells, and in vitrofluorescent signal was detected at various times post-infection by fluorescence microcopy, and morphological changes of recombinant Ad- detection of fluorescently labeled
Figure 4: In vitro anti-tumor effects of recombinant Ad vectors. Normal cells and tumor cells were infected with rAd5-RFP, rAd5-zTRAIL-RFP, rAd5pz-zTRAIL-RFP, rAd5-zTRAIL-RFP-SΔ24E1a or rAd5pz-zTRAIL-RFP-SΔ24E1a at different MOI (0.01, 0.05, 0.25, 1.25, 6.
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