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Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract

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Figure

Fig. 1. Removal of Shh and Ihh activities in the developingmouse gut. embryos. Wholemount images of the isolated digestive tract, includingstomach and intestine, at E11.5, E12.5, E14.5 and E16.5
Fig. 2. Digestive tract growth and differentiationin the developing stomach (St) and adjoining spleno(Sp)-pancreatic (Pa) primordium in mutant (right) and control (compound micrographs from control (left) embryos showing mesenchymalexpansion and smooth mus
Fig. 4. Mesenchymal differentiation of Shhimmunostaining in control and blood vessels are present in the mesenchyme of ShhCD31 immunostaining at E12.5
Fig. 5. Hh ligands promote proliferation of fetal GI mesenchymalcells.isolated from wild-type E12.5 embryos and cultured in the presence ofincreasing concentrations (G) of recombinant N-Shh for 3 days, or fordifferent periods in 20 mM N-Shh (H)
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