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CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis

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Figure

Figure 1: Inducible CIP4 silencing and EGFR activation in TNBC cells alters EGFR signaling
Figure 2: CIP4 silencing alters EGFR signaling to Akt and ERK kinases. (A)with Dox (2 μg/ml for 48 hours) prior to serum starvation and treatment with EGF (50 ng/ml) for the indicated times (min.)
Figure 3: CIP4 promotes TNBC cell invasion. (A) Representative phase contrast images of spheroid colonies for MDA-MB-231 Tripz or shCIP4 (day 3) and following addition of invasion matrix (day 10, invasion)
Figure 4: CIP4 promotes TNBC metastasis to the lungs in mice. (A) Graph depicts primary tumor masses for mammary orthotopic xenograft assays using MDA-MB-231 and MTLn3-PL models (vector or shCIP4)
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